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Combinatorial remedy rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas

Dinero Post by Dinero Post
March 18, 2023
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  • Phelan, J. D. et al. A multiprotein supercomplex controlling oncogenic signalling in lymphoma. Nature 560, 387–391 (2018).

    Article 
    CAS 

    Google Scholar 

  • Chapuy, B. et al. Molecular subtypes of diffuse giant B cell lymphoma are related to distinct pathogenic mechanisms and outcomes. Nat. Med. 24, 679–690 (2018).

    Article 
    CAS 

    Google Scholar 

  • Roschewski, M., Staudt, L. M. & Wilson, W. H. Diffuse giant B-cell lymphoma-treatment approaches within the molecular period. Nat. Rev. Clin. Oncol. 11, 12–23 (2014).

    Article 
    CAS 

    Google Scholar 

  • Lenz, G. et al. Oncogenic CARD11 mutations in human diffuse giant B cell lymphoma. Science 319, 1676–1679 (2008).

    Article 
    CAS 

    Google Scholar 

  • Fontan, L. et al. Identification of MALT1 suggestions mechanisms allows rational design of potent antilymphoma regimens for ABC-DLBCL. Blood 137, 788–800 (2021).

    Article 
    CAS 

    Google Scholar 

  • Wilson, W. H. et al. Concentrating on B cell receptor signaling with ibrutinib in diffuse giant B cell lymphoma. Nat. Med. 21, 922–926 (2015).

    Article 
    CAS 

    Google Scholar 

  • Younger, R. M. & Staudt, L. M. Concentrating on pathological B cell receptor signalling in lymphoid malignancies. Nat. Rev. Drug Disco. 12, 229–243 (2013).

    Article 
    CAS 

    Google Scholar 

  • Younger, R. M., Phelan, J. D., Wilson, W. H. & Staudt, L. M. Pathogenic B-cell receptor signaling in lymphoid malignancies: new insights to enhance remedy. Immunol. Rev. 291, 190–213 (2019).

    Article 
    CAS 

    Google Scholar 

  • Schmitz, R. et al. Genetics and pathogenesis of diffuse giant B-cell lymphoma. N. Engl. J. Med. 378, 1396–1407 (2018).

    Article 
    CAS 

    Google Scholar 

  • Fontan, L. et al. MALT1 small molecule inhibitors particularly suppress ABC-DLBCL in vitro and in vivo. Most cancers cell 22, 812–824 (2012).

    Article 
    CAS 

    Google Scholar 

  • Solar, L., Deng, L., Ea, C. Okay., Xia, Z. P. & Chen, Z. J. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell 14, 289–301 (2004).

    Article 
    CAS 

    Google Scholar 

  • Hailfinger, S. et al. Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell traces. Proc. Natl Acad. Sci. USA 108, 14596–14601 (2011).

    Article 
    CAS 

    Google Scholar 

  • Fontan, L. et al. Particular covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma development. J. Clin. Make investments. 128, 4397–4412 (2018).

    Article 

    Google Scholar 

  • Nagel, D. et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic method for the remedy of aggressive ABC-DLBCL. Most cancers Cell 22, 825–837 (2012).

    Article 
    CAS 

    Google Scholar 

  • Kotlov, N. et al. Medical and organic subtypes of B-cell lymphoma revealed by microenvironmental signatures. Most cancers Discov. 11, 1468–1489 (2021).

    Article 
    CAS 

    Google Scholar 

  • Wright, G. W. et al. A probabilistic classification device for genetic subtypes of diffuse giant B cell lymphoma with therapeutic implications. Most cancers Cell 37, 551–568 e514 (2020).

    Article 
    CAS 

    Google Scholar 

  • Scott, D. W. & Gascoyne, R. D. The tumour microenvironment in B cell lymphomas. Nat. Rev. Most cancers 14, 517–534 (2014).

    Article 
    CAS 

    Google Scholar 

  • Elgueta, R. et al. Molecular mechanism and performance of CD40/CD40L engagement within the immune system. Immunol. Rev. 229, 152–172 (2009).

    Article 
    CAS 

    Google Scholar 

  • Ito, D. et al. CD40 ligand is important and ample to assist main diffuse giant B-cell lymphoma cells in tradition: a device for in vitro preclinical research with main B-cell malignancies. Leuk. Lymphoma 53, 1390–1398 (2012).

    Article 
    CAS 

    Google Scholar 

  • Nojima, T. et al. In-vitro derived germinal centre B cells differentially generate reminiscence B or plasma cells in vivo. Nat. Commun. 2, 465 (2011).

    Article 

    Google Scholar 

  • Ennishi, D. et al. Molecular and genetic characterization of MHC deficiency identifies EZH2 as therapeutic goal for enhancing immune recognition. Most cancers Discov. 9, 546–563 (2019).

    Article 

    Google Scholar 

  • Reddy, A. et al. Genetic and purposeful drivers of diffuse giant B cell lymphoma. Cell 171, 481–494.e415 (2017).

    Article 
    CAS 

    Google Scholar 

  • Ni, C. Z. et al. Molecular foundation for CD40 signaling mediated by TRAF3. Proc. Natl Acad. Sci. USA 97, 10395–10399 (2000).

    Article 
    CAS 

    Google Scholar 

  • Phelps, E. A. et al. Maleimide cross-linked bioactive PEG hydrogel reveals improved response kinetics and cross-linking for cell encapsulation and in situ supply. Adv. Mater. 24, 64–70 (2012). 62.

    Article 
    CAS 

    Google Scholar 

  • Graney, P. L. et al. Organoid polymer performance and mode of Klebsiella pneumoniae membrane antigen presentation regulates ex vivo germinal heart epigenetics in younger and aged B cells. Adv. Funct. Mater. 30, 2001232 (2020).

    Article 
    CAS 

    Google Scholar 

  • Lutolf, M. P. & Hubbell, J. A. Synthesis and physicochemical characterization of end-linked poly(ethylene glycol)-co-peptide hydrogels fashioned by Michael-type addition. Biomacromolecules 4, 713–722 (2003).

    Article 
    CAS 

    Google Scholar 

  • Rodda, L. B. et al. Single-cell RNA sequencing of lymph node stromal cells reveals niche-associated heterogeneity. Immunity 48, 1014–1028 e1016 (2018).

    Article 
    CAS 

    Google Scholar 

  • Massia, S. P. & Hubbell, J. A. Vascular endothelial cell adhesion and spreading promoted by the peptide REDV of the IIICS area of plasma fibronectin is mediated by integrin α 4 β 1. J. Biol. Chem. 267, 14019–14026 (1992).

    Article 
    CAS 

    Google Scholar 

  • Rydholm, A. E., Bowman, C. N. & Anseth, Okay. S. Degradable thiol-acrylate photopolymers: polymerization and degradation conduct of an in situ forming biomaterial. Biomaterials 26, 4495–4506 (2005).

    Article 
    CAS 

    Google Scholar 

  • Quancard, J. et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing operate in an immunodeficient affected person. Nat. Chem. Biol. 15, 304–313 (2019).

    Article 
    CAS 

    Google Scholar 

  • Richards, Okay. L. et al. Gene profiling of canine B-cell lymphoma reveals germinal heart and postgerminal heart subtypes with totally different survival occasions, modeling human DLBCL. Most cancers Res. 73, 5029–5039 (2013).

    Article 
    CAS 

    Google Scholar 

  • Tolar, P., Hanna, J., Krueger, P. D. & Pierce, S. Okay. The fixed area of the membrane immunoglobulin mediates B cell-receptor clustering and signaling in response to membrane antigens. Immunity 30, 44–55 (2009).

    Article 
    CAS 

    Google Scholar 

  • Clark, A. Y. et al. Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative actions. Nat. Commun. 11, 114 (2020).

    Article 
    CAS 

    Google Scholar 

  • Arnaout, M. A., Mahalingam, B. & Xiong, J. P. Integrin construction, allostery, and bidirectional signaling. Annu. Rev. Cell Dev. Biol. 21, 381–410 (2005).

    Article 
    CAS 

    Google Scholar 

  • Bellis, S. L. Benefits of RGD peptides for guiding cell affiliation with biomaterials. Biomaterials 32, 4205–4210 (2011).

    Article 
    CAS 

    Google Scholar 

  • Knight, C. G. et al. Identification in collagen kind I of an integrin alpha2 beta1-binding web site containing a necessary GER sequence. J. Biol. Chem. 273, 33287–33294 (1998).

    Article 
    CAS 

    Google Scholar 

  • Zeltz, C. & Gullberg, D. The integrin-collagen connection—a glue for tissue restore? J. Cell Sci. 129, 653–664 (2016).

    Article 
    CAS 

    Google Scholar 

  • Arana, E., Harwood, N. E. & Batista, F. D. Regulation of integrin activation by way of the B-cell receptor. J. Cell Sci. 121, 2279–2286 (2008).

    Article 
    CAS 

    Google Scholar 

  • Carrasco, Y. R. & Batista, F. D. B‐cell activation by membrane‐sure antigens is facilitated by the interplay of VLA‐4 with VCAM‐1. EMBO J. 25, 889–899 (2006).

    Article 
    CAS 

    Google Scholar 

  • Weekes, C. D., Kuszynski, C. A. & Sharp, J. G. VLA-4 mediated adhesion to bone marrow stromal cells confers chemoresistance to adherent lymphoma cells. Leuk. Lymphoma 40, 631–645 (2001).

    Article 
    CAS 

    Google Scholar 

  • Headen, D. M. et al. Native immunomodulation Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance. Nat. Mater. 17, 732–739 (2018).

    Article 
    CAS 

    Google Scholar 

  • Landon, A. L. et al. MNKs act as a regulatory swap for eIF4E1 and eIF4E3 pushed mRNA translation in DLBCL. Nat. Commun. 5, 5413 (2014).

    Article 

    Google Scholar 

  • Manning, G., Whyte, D. B., Martinez, R., Hunter, T. & Sudarsanam, S. The protein kinase complement of the human genome. Science 298, 1912–1934 (2002).

    Article 
    CAS 

    Google Scholar 

  • Zheng, M. et al. A mixture of S and ΔS variants of STAT3 allow survival of activated B-cell-like diffuse giant B-cell lymphoma cells in tradition. Oncogenesis 4, e184 (2016).

    Article 
    CAS 

    Google Scholar 

  • Apoorva, F. N. U. et al. Lymph node stiffness-mimicking hydrogels regulate human B-cell lymphoma development and cell floor receptor expression in a molecular subtype-specific method. J. Biomed. Mater. Res. A 105, 1833–1844 (2017).

    Article 
    CAS 

    Google Scholar 

  • Ohto, U. et al. Structural foundation of CpG and inhibitory DNA recognition by Toll-like receptor 9. Nature 520, 702–705 (2015).

    Article 
    CAS 

    Google Scholar 

  • Scuoppo, C. et al. Repurposing dasatinib for diffuse giant B cell lymphoma. Proc. Natl Acad. Sci. USA 116, 16981–16986 (2019).

    Article 
    CAS 

    Google Scholar 

  • Battistello, E. et al. Pan-SRC kinase inhibition blocks B-cell receptor oncogenic signaling in non-Hodgkin lymphoma. Blood 131, 2345–2356 (2018).

    Article 
    CAS 

    Google Scholar 

  • Gopal, A. Okay. et al. PI3Kδ inhibition by idelalisib in sufferers with relapsed indolent lymphoma. N. Engl. J. Med. 370, 1008–1018 (2014).

    Article 
    CAS 

    Google Scholar 

  • Kim, S., Shah, S. B., Graney, P. L. & Singh, A. Multiscale engineering of immune cells and lymphoid organs. Nat. Rev. Mater. 4, 355–378 (2019).

    Article 

    Google Scholar 

  • Liao, Y., Smyth, G. Okay. & Shi, W. featureCounts: an environment friendly normal function program for assigning sequence reads to genomic options. Bioinformatics, 30(7):923–30 (2014).

  • Robinson, M. D., McCarthy, D. J. & Smyth, G. Okay. edgeR: a Bioconductor package deal for differential expression evaluation of digital gene expression information. Bioinformatics, 26(1), 139–140 (2010); https://doi.org/10.1093/bioinformatics/btp616

  • Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Legislation, C. W., Shi, W. & Smyth, G. Okay. limma powers differential expression analyses for RNA-sequencing and microarray research. Nucleic Acids Res., 43(7), e47 (2015); https://doi.org/10.1093/nar/gkv007

  • Kolde, R. pheatmap: Fairly Heatmaps. R package deal model 1.0.12 (2019).

  • Shen, Y. et al. Oncogenic function of the SOX9–DHCR24–ldl cholesterol biosynthesis axis in IGH-BCL2+ diffuse giant B-cell lymphomas. Blood 139, 73–86 (2022).

    Article 
    CAS 

    Google Scholar 

  • Stringer, C., Wang, T., Michaelos, M. & Pachitariu, M. Cellpose: a generalist algorithm for mobile segmentation. Nat Strategies 18, 100–106 (2021).

    Article 
    CAS 

    Google Scholar 

  • Apoorva, F. et al. How biophysical forces regulate human B cell lymphomas. Cell Rep. 23, 499–511 (2018).

    Article 
    CAS 

    Google Scholar 

  • Purwada, A. et al. Ex vivo engineered immune organoids for managed germinal heart reactions. Biomaterials 63, 24–34 (2015).

    Article 
    CAS 

    Google Scholar 

  • Purwada, A. et al. Ex vivo artificial immune tissues with T cell alerts for differentiating antigen-specific, excessive affinity germinal heart B cells. Biomaterials 198, 27–36 (2019).

    Article 
    CAS 

    Google Scholar 

  • Purwada, A., Shah, S. B., Beguelin, W., Melnick, A. M. & Singh, A. Modular immune organoids with integrin ligand specificity differentially regulate ex vivo B cell activation. ACS Biomater. Sci. Eng. 3, 214–225 (2017).

    Article 
    CAS 

    Google Scholar 



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